Process separation in the energy industry involves complicated chemical, mechanical, and electrical processes often working in unison. There are several variables that must be monitored and adjusted for optimal separation of the fluids. Identifying the optimal set points of the flow variables is challenging even with reliable analytical instrumentation. ProSITE is a software package that combines more than 50 years of process separation experience with digitally enabled process equipment. In the upstream oil separation process, for example, ProSITE will use live data from several relevant variables of the crude oil separation process and combine that with machine learning models to determine the most efficient rates of emulsifier injection. The optimal rates are then fed back to the chemical injection pumps for a complete automated and reliable demulsifier injection loop.